Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment
Biologics [e.g., TNF- inhibitors (etanercept), IL-6R blockers (tocilizumab)]: Effective in 60 - 70% of patients but incur prohibitive costs ($20,000 - 50,000 annually), limiting accessibility (only 10 - 20% treated in low-resource settings) (5, 6)
Notably, EVs extracted from ACE2-expressing cells have been nebulized as ACE2 decoys 51,52,53,54

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This innovative peptide, delivered through advanced topical cream formulations, offers localized fat-mobilizing effects without systemic side effects
Collectively, we observed that secreted factors and EVs from MST6-I cells induce a phenotypic change in adipocytes, consistent with browning and lipolytic remodeling of white adipocytes, to a greater extent than either the Mock secretome or derived EVs