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On presentation to the emergency department, his vitals were: Heart rate 119 bpm Blood pressure 86/47 mmHg Pulse oximetry 77 percent on nonrebreather Respiratory rate 20 Temperature 34.2 degrees C He required endotracheal intubation and dual pressor support with norepinephrine and vasopressin

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10.1089/ars.2016.6954 44 KutlarA.JoshiV.BruecknerA.KanterJ.LilesD

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The mechanisms involve the inhibition of the enzyme activity rather than the production of MCR-1 by ISA, restoring the efficacy of carbapenems (Lu N

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