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Cancer cells treated with ATN-224 undergo programmed caspase-mediated apoptosis both in vitro and in vivo, indicating that SOD1 may act as a tumor promoter and represents a promising novel target for cancer treatment (Glasauer et al

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R., Tharakan, M., George, L., & Koshy, S

Furthermore, glutamate taken up through GLT-1 may be used for direct incorporation into glutathione and to fuel the intracellular glutamate pool to allow cystine uptake through the x c system

The heart, liver, lung, kidney and tumor tissues of each mouse were completely extracted and weighed