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Research was performed according to the principles of the Declaration of Helsinki of 2013

doi: 10.1038/s41591-025-03600-2 106 LuGNishioNvan den BergNSMartinBAFakurnejadSKeulenSvet al

J Endocrinol Investig 11:599602 Salgado LR, Semer M, Nery M, Knoepfelmacher M, Lerrio AC, Pvoa G, Jana S, Villares SM, Wajchenberg BL, Liberman B, Nicolau W (1996) Effect of glycemic control on growth hormone and IGFBP-1 secretion in patients with type I diabetes mellitus

Research goals: Metabolic & Weight Description AOD-9604 (CAS 221231-10-3) is a synthetic 16-amino-acid peptide corresponding to the C-terminal fragment of human growth hormone (hGH 177191) with an additional N-terminal tyrosine added to enhance stability

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Hormonal Changes : Factors such as pregnancy, hormonal therapies, or conditions like melasma can alter melanin production