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However, multiple limitations in preclinical studies reduce the significance of current findings

5.1 Protein carbonylation in type 2 diabetes T2D patients show elevated RLAs and PC levels in plasma, urine, liver, retina, skeletal muscle, lymphocytes, red blood cells, adipose tissue and islets (148, 149, 151164)

HPXRs play an important role in macrophage function in the immune system because heme from 59 FehemeHPX was efficiently incorporated into myeloperoxidase, a heme-protein in differentiated HL-60 cells (Vestal et al., 1990) and into cytochrome P-450 apo-protein ( 3.1 Isolation and identification of hemeHPX binding proteins in human HL-60 cells The HPX-binding scavenger receptor LRP1 is expressed by certain human immune cells, e.g