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These class II CFTR variants are associated with altered structural conformation, and this misfolded CFTR proteins is degraded by the chaperons mediated Endoplasmic Reticulum-Associated Degradation (ERAD) pathway

Aging Cell 19 , e13232 (2020)

Y.QuelizaK.Nagy-SzakalD.StewartC

If a patient is already taking GTE supplements or insists on continuing them against advice, the monitoring interval should tighten

Afterwards, excessive ROS would interfere with Ca 2+ homeostasis in cardiomyocytes, affecting multiple ion transporters responsible for myocardial electrical activity and bringing about diastolic and systolic dysfunction and arrhythmia

[DOI] [PubMed] [Google Scholar] [87].Yang IY, Chan G, Miller H, Huang Y, et al