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Nature 373: 702705 [DOI] [PubMed] [Google Scholar] Ueki T., Kaneda Y., Tsutsui H., Nakanishi K., Sawa Y., Morishita R., et al

The charged nature contributes to water solubility while the lipophilic quinoline ring enables cellular membrane penetration

Christie, M.C

It first acts by shutting off executive functions like judgment, mood control and natural inhibitions

Budni, A.C.B

Subsequent enzyme activity assays confirmed that aspirin markedly impaired the activity of a number of key enzymes required for these acetyl-CoA pathways in MnSOD-deficient cells, but not in wild-type cells