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Cagrilintide is a synthetic long-acting amylin analogue

However, systemic administration for pathologies local to the auris interna increases the likelihood of systemic toxicities and side effects and creates a non-productive distribution of drug in which high levels drug are found in the serum and correspondingly lower levels are found at the auris interna

Cagrilintide is a long-acting amylin analogue acting on a completely different receptor family (AMY1R/AMY2R/AMY3R)

Cent European J Urol

Evaluation of colistin nephrotoxicity administered at different doses in the rat model

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