glutathione peroxidase gsh-px inhibited by zinc deficiency ncbi Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging Mathematical model for glutathione dynamics

The studies of water release or rebinding to the coproduct formation site have shown that compound I intermediate might exist in two forms either in a wet form in which a water molecule is present at or near the site of coproduct water formation or dry form where the coproduct water formation site is dry

Through injection of -syn preformed fibrils (PFFs) into the striatum of transgenic mice, researchers demonstrated the development of Lewy pathology, nigrostriatal degeneration, and importantly expanded our understanding of cell-to-cell transmission by describing the nature of spread in neuroanatomically connected regions: this provided the first evidence that synthetic -syn PFFs alone can induce the initiation and propagation of -syn pathology in vivo (Luk et al., 2012)

In diabetic animals, the effect of exogenous GABA on circulating glucagon and/or -cell mass are conflicting

Proof of principle for crizotinib in anaplastic lymphoma kinase-positive malignancies was achieved in ALK-positive nonclinical models

Music prevents stress-induced depression and anxiety-like behavior in mice

Cullin 5 aggravates hypoxic pulmonary hypertension by activating TRAF6/NF-B/HIF-1/VEGF