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However, a trial involving 22,845 AD patients showed that those treated with AChEIs had higher risks of appetite disorders, insomnia, or depression compared to those receiving a placebo (Bittner et al., 2023), indicating that modern clinical drugs come with certain side effects

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This proportion varies with geography, genetic factors, gender and age

Although their potential has been greatly increased, additional studies are required to fully grasp their therapeutic benefits, especially through human clinical trials and advanced delivery systems

[DOI] [PubMed] [Google Scholar] 58.Rizzello CG, Portincasa P, Montemurro M, Di Palo DM, Lorusso MP, De Angelis M, Bonfrate L, Genot B, Gobbetti M