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Study 4 evaluated neuronal activation in response to acute treatment with Cagrilintide or sCT in WT, RAMP1 KO, RAMP3 KO, and RAMP1/3 KO mice

Compliance Both arms had similarly high compliance to the study treatment, with the average compliance across all 6 months being 95.4% and 95.7% in the intervention and placebo arms, respectively

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The mGlu2 receptor promoter harbors numerous NF-B responsive elements, as opposed to the promoter of the cognate receptors, mGlu3

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