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Foundational NNMT Discoveries The foundational research establishing NNMT as a metabolic regulator and potential therapeutic target came from studies by Daniel Kraus and colleagues published in Nature in 2014, which demonstrated that NNMT expression is dramatically upregulated in adipose tissue of obese humans and diet-induced obese mice, and that genetic knockdown of NNMT in mice protected against diet-induced obesity and improved metabolic parameters

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This distinguishes Zepbound from certain other weight management products that may combine medications with vitamins

doi: 10.3390/ijms232415982

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5-Amino-1MQ, as an NNMT inhibitor, alters a pathway involved in NAD+ and methylation balance, and its long-term effects in people are simply unstudied