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A meta-analysis of 28 studies with 74,660 patients who had bioprosthetic valves and atrial fibrillation showed that DOACs were more effective in reducing the risks of bleeding, strokes, systemic embolism, and intracranial bleeding when compared to warfarin

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The release of HGF, in conjunction with c-MET, triggers subsequent processes that result in STAT3 phosphorylation, thereby facilitating the growth of functional MDSCs [81]