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UPF addiction has been found to lead to neural responses that are similar to those that are seen in substance addiction, and these responses include a greater anticipatory reward, reduced consummatory reward, and enhanced functional connectivity in reward processing neurons (132)

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Certain CYP isoformsnotably CYP2E1are potent sources of ROS, especially upon induction (e -TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner

doi: 10.1016/0891-5849(94)90197-x

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