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Jan 2021;45(1):22-31

Thus, we generated pRE-1 and pRE-2 constructs by cloning the 791 bp (739 to +51) and 808 bp (+3493 to +4300) fragments containing these putative p53-binding elements, which were then fused with SV40 promoter, and inserted into the pGL3 luciferase reporter vector

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CAFs affect the toughness of ECM and enhance cell invasiveness by inducing epithelial-mesenchymal transformation (EMT), which is conducive to metastasis and dissemination (69)