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Oral supplementation has gained popularity for skin brightening, immune support, and cellular repair

675 Although the above small molecule compounds can prevent iron overload-related diseases by regulating iron metabolism, only DFO, DPF, and DFX are currently approved for clinical use

Collectively, these factors highlight the need for carefully designed therapies that can selectively target GSH in tumors while minimizing toxicity and overcoming adaptive resistance mechanisms

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Mandell JG, Barbas CF (2006) Zinc finger tools: custom DNA-binding domains for transcription factors and nucleases

However, it is important to note that the ferroptosis-protective role of DHODH remains a matter of ongoing debate and appears to be highly context- and cell-type-dependent [94]