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doi: 10.1016/j.biopha.2018.10.121

Rethinking IL-6 and CRP: why they are more than inflammatory biomarkers, and why it matters

The H571 residue was confirmed to be the residue responsible for the deprotonation of the C159 thiol, increasing its reactivity and generating the prominent thiolate-FAD charge transfer absorption that accumulates with oxidation of the flavin

& Perkovic, V

Funding This work was supported by grants from the Research Fund of Erzincan Binali Yldrm University (Project number: TSA-2021-793)

As previously discussed, elevated levels of labile iron promote the generation of lipid peroxides, which are highly cytotoxic and further exacerbate neuronal dysfunction ( Ferroptosis, a regulated form of cell death, plays a significant role in the initiation, progression, and outcomes of AD