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The mechanism behind this phenomenon may involve several aspects, including oxidative stress, inflammatory responses, and accumulation of advanced glycation end products (AGEs)

When a CpG island in the promoter region of a gene is methylated, expression of the gene is repressed (it is turned off)

Histone deacetylase inhibitors, like 4-phenylbutyrate and sodium butyrate, can induce histone acetylation but show limited effects when used alone (218)

Metals, including lead, mercury, aluminum and arsenic, can cause short- and long-term health consequences since they impact functions of the central nervous, cardiovascular, immune and skeletal systems

[9] Synthesis and function of sulfur compounds in plants [edit] Cysteine [edit] Sulfide is incorporated into cysteine, catalyzed by O-acetylserine (thiol)lyase, with O-acetylserine as substrate

Buthionine sulfoximine (BSO), 1, 3-bis (2-chloroethyl)-1-nitrosourea (BCNU), diamide, and Hoechst 33342 were purchased from Sigma (St