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Spotted fever has increased in incidence from approximately 500 cases in the year 2000 to 6248 cases in 2017, and disease occurs in every state of the continental United States 1

We acknowledge the Robotein platform of the BE Instruct-ERIC Centre for providing access to their equipment

Such a situation would be similar to allergen immunotherapy, whereby repeated low-dose antigen administration in the absence of inflammation results in antigen-blocking IgG4