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Description

Javitt et al

438 Pangrazzi et al

Materials and methods Corn hydrolysate The corn hydrolysate was prepared in a continuously stirred tank reactor equipped with constant agitation and temperature control

Temporal evolution of biomarkers and cognitive markers in the asymptomatic, MCI, and dementia stage of Alzheimers disease

In the first ascending dose, open-label study (NCT02464605), pegadricase, an immunogenic, pegylated uricase enzyme derived from Candida utilis , is assessed for safety and tolerability (primary endpoint) as well as activity and immunogenicity (secondary endpoint)

Structure determination and refinement The crystal structure of the apo form of Hpy GS was solved by molecular replacement using the GS structure from S