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Description

These morphological alterations completely mirror decreased function in dorsomedial PFC and dorsolateral PFC and provide strong support for the hypothetical impairment of neuroplasticity in bipolar disorder (144)

A suggested approach for future application of this methodology would be to characterize specific abnormalities in iPSC-derived DA neurons from subjects with prevalent or persistent NS, and use them to test novel pharmacologic agents/AP aimed to revert these changes in vitro