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10.1038/s41586-019-1167-6 212 SinghU.DevarajS.JialalI

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Combining drugs from different classes is now considered the standard of care and has been demonstrated to improve outcomes

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The metabolic derangements incorporate PDHC and TCA cycle defects: increased blood lactate and pyruvate, elevated plasma alanine, BCAA, presence of allo-isoleucine in plasma, and increased urinary lactic, pyruvic, 2-ketoglutaric, and branched-chain 2-hydroxy- and 2-ketoacid [143,144]

Despite significant advances in elucidating GBM pathogenesis, further research is required to deepen understanding of its underlying mechanisms