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Researchers propose that MOTS-c acts as an endocrine-like factor a mitochondrial hormone that helps coordinate metabolism and stress responses across the body, thereby affecting the aging process

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With the onset of IDD, IVD, especially NP, undergoes a progressive dehydration due to proteolytic cleavage of aggrecan together (Karppinen et al., 2011), a substantial reduction of resident cell viability (Vergroesen et al., 2015)