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The Lancet Gastroenterology and Hepatology , 1 (3), 226237

In the mevalonate pathway, the enzyme 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase, which converts HMG-CoA into mevalonate, is common to the biosynthetic pathways of both coenzyme Q 10 and cholesterol and is inhibited by statins (cholesterol-lowering drugs

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Cells are predisposed to oxidative stress when their anti-oxidant contents are low or their ROS levels high

It is believed that more in-depth studies will explore and reveal the current limited molecular mechanism of ferroptosis, thus providing more enough scientific basis for the clinical application of targeting ferroptosis to the prevention and treatment of AS