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In addition to the PXR, several other nuclear receptors exist including the retinoid X receptor (RXR), the farnesoid X receptor (FXR), and the constitutive androstane receptor (CAR) which all have similar inductive effects on other CYP450 enzymes.15 So what does this all mean for individuals taking or tapering off of psychiatric medications

Similarly, our primary culture experiment showed that piperine treatment induced glucose uptake via AMPK-p38 MAPK activation, resulting in greater translocation of Glut4 into the plasma membrane, thereby activating glucose uptake through the AMPK and p38 MAPK signaling pathway in skeletal muscle

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Overall, PHH and PRH exhibited 100% specificity in detecting both carcinogenic and in vitro/in vivo mutagenic NAs correctly

Hickson et al., 2025)

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