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Avoid repeated freeze-thaw cycles and keep materials in their original sealed container until ready for use

Riccio A, Alvania RS, Lonze BE, Ramanan N, Kim T, Huang Y et al

[0335] In some embodiments, the dispersity, or measure of heterogeneity in size of molecules (PDI), of LNPs in a pharmaceutical composition provided by the present disclosure is less than about 0.5

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Note: The above statements have not been evaluated by the Food and Drug Administration