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When the study protocol was over, the mice were euthanized by inhaling 5% (overdose) isofurane and immediately after 60 s as the animals no longer have a heartbeat and have whitish eyes, cervical dislocation was performed to ensure euthanasia

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, VHL deletion) or reactive oxygen species (ROS) under normoxia, compounded by tumor vascular abnormalities inducing regional hypoxia ( Figure 1 )

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