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The regorafenib investigational arm was concurrently and adaptively randomized against other investigational arms, and regorafenib was ultimately dropped after interim analysis showed a low probability of sufficient improvement in OS as compared with randomized controls

only combined Tet1/Tet2 double knockout causes pronounced 5mC accumulation and developmental failure, although some double-knockout mESCs can still contribute to chimeras 84,85

The GCLM -588T allele has been associated in published studies with lower plasma cysteine levels and reduced lymphocyte GSH concentrations in healthy adults