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Journal of Molecular Endocrinology, 52 (1)

A Certificate of Analysis (COA) from an accredited third-party laboratory is the minimum standard of verification

GHRH pulses primarily determine the amplitude of GH secretory bursts by maintaining somatotroph GH synthesis capacity and directly stimulating release during permissive periods when somatostatin tone is low

Even at doses 200-fold above the effective GH-releasing dose, ipamorelin did not stimulate cortisol demonstrating a true selectivity threshold rather than merely a dose-separation effect