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However, it is noteworthy that within the organic acidemia cohort, five patients had biochemical evidence of attenuated microbial carnitine-TMAO conversion, e.g., low-to-normal plasma TMAO levels

C., & Zhang, J

G., Duerden, B

27 Furthermore, some research indicates that intestinal bacteria can break down carnitine to form a substance called TMAO that might increase the risk of cardiovascular disease, particularly in those who eat a meat and egg rich diet

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Under physiological conditions, LCACs have the capacity to regulate the current amplitude and kinetics of hERG channels in the heart, which have important effects on arrhythmia [121]