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curcumin remains relatively stable below pH 6.5 but becomes highly labile in neutral-to-alkaline conditions due to deprotonation of phenolic groups, which disrupts its conjugated diene structure and accelerates autoxidation [62, 63]

In summary, PCs regulate the function of glucose-targeting organs, modulate glucose metabolism and synthesis, and maintain glucose homeostasis through multiple pathways

Bax protein is a proapoptotic member that acts by forming pores on the mitochondrial outer membrane, allowing cytochrome c to translocate into the cytoplasm, resulting in the loss of energy production and the activation of proteolytic cascade leading to apoptosis (Westphal et al., 2014)

Transnasal delivery of the peptide agonist specific to neuromedin-U receptor 2 to the brain for the treatment of obesity

This deactivation of MKPs allows for the unimpeded progression and sustained activation of the pro-inflammatory ERK1/2, JNK, and p38 signaling cascade within the MAPK pathway (Son et al., 2011)