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Since sepsis was usually caused by bacteria of enteric origin, the supposition was made that intestinal bacteria can translocate across the intestinal barrier under stress when the structural or functional integrity of the intestinal barrier is compromised

Although these technologies are still in the experimental stage and lack sufficient clinical data, nanosystems represent promising strategies for delivering peptides [133]

The three primary stability threats are elevated temperature, ultraviolet light exposure, and mechanical agitation all of which promote aggregation and denaturation of the peptide chains