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Site S5 is composed of residues from the TrxR and Grx domains, lying over the FAD binding subdomain (Suppl

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5 Summary and future perspectives In summary, in the pathogenesis of DR, prolonged hyperglycemia affects the normal physiological function of RMCs, leading to the disturbances in the retinal water-ion balance, disruption of the BRB, imbalance in the homeostasis of the retinal microenvironment, and the secretion of pro-inflammatory cytokines and chemokines following RMCs overactivation

Free Radic Biol Med 15: 195202

1 Introduction DNA methylation is a major covalent modification occurring at the C-5 position of cytosine in CpG dinucleotides, with cofactor S-adenosyl-l-methionine (SAM) as a methyl donor, which suppresses the transcription of the methylated gene (Costa et al., 2017)