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Serine from SSP can directly bind to pyruvate kinase M2 (PKM2), the last rate-limiting enzyme of glycolysis, and promote the allosteric activation of PKM2 for the positive feedback of continuously activated glycolysis and serine synthesis (Chaneton et al., 2012)

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b , Immunoblot of SLC25A39, SLC25A12 and CS in HeLa cells treated with the indicated doses of BSO for 24 h

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