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133 In summary, inflammatory signals and metabolic imbalance within the context of gut barrier impairment and microbiota dysbiosis exert a long-range effect on skeletal muscle homeostasis, exacerbating their negative nitrogen balance, wherein the synthesis of skeletal muscle proteins falls below their breakdown rates

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Therapies enhancing GSH could become a cornerstone to reduce severity and fatal outcomes of COVID-19 disease and increasing GSH levels may prevent and subdue the disease

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Take GLP-1R for example, which is a class B G-protein-coupled receptor (GPCR), and plays a pivotal role in glucose homeostasis by mediating the pharmacological effects of GLP-1 agonists [21, 22]