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A meta-analysis of 10 randomized controlled trials that included 643 patients with advanced solid tumors using melatonin as the sole therapy or adjuvant therapy reported that melatonin treatment reduced the risk of death at 1 year [54]

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Dopaminergic neurons in the substantia nigra , the brain region most affected by Parkinson's disease, express receptors for an inflammatory cytokine called tumor necrosis factor-alpha (TNF-) , which suggests that excess TNF- released by nearby activated microglia may damage nigral dopaminergic cells

Vitamin B6 contributes to normal psychological function

(2021) recruited 61 patients with HFpEF patients as controls and found that plasma TMAO levels were highly correlated with the risk of HFpEF

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