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Related citrus fruits, such as Seville oranges, may cause similar effects

Double strand DNA activates endosomal TLR9, or RNAs activate cytosolic nucleic acid sensors MDA5 or RIG-1, all of which result in activation of IRF7

Lozada-Fernndez et al

Axonal damage and glial response accompanying demyelination were more severe and prolonged in aged (67 months) as compared to young (810 weeks) mice (Irvine and Blakemore, 2006)