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Hirotsu, Y., et al., Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks

Y., Im, Y

Patients who wish to see significant improvement in discolorations associated with severe hyperpigmentation, melasma or uneven skin tone may need to be treated at higher doses, or over a longer period of time than patients seeking skin lightening

[Google Scholar] 165.Ministry of Health of Brazil

This shift came with an increase in certain Firmicutes bacteria, especially Clostridium species and Erysipelotrichaceae

Renal function must be assessed, as high-dose vitamin C can cause oxalate nephropathy in patients with compromised kidney function