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Long-standing GERD with significant esophageal damage may require longer treatment periods and show slower response compared to milder, more recent-onset reflux

This growing global distribution highlights the urgent need for early detection, preventive screening, and integrative approaches that address both disease management and long-term quality of life [3][2]

Real-world application still requires further scrutiny, time, and frank conversations with clinicians

However, while mechanistic insights from the aforementioned studies are based on the acute MPTP model, CD4 + T cell infiltration occurs earlier in the subacute model (208)

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