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Well start with the most obvious one

doi:10.1113/JP287535 Dahl K, et al

Start conservatively at 0.25 mg daily for the first week to assess tolerance before increasing to 0.5 mg if needed

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Abstract Loss of sensory hair cells from exposure to certain licit drugs (e.g., aminoglycoside antibiotics, platinum-based chemotherapy agents) can result in permanent hearing loss

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