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Although large-scale orthopaedic trials are lacking, animal studies and indirect clinical evidence provide a biologic rationale for their use

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Additionally, adopting healthy lifestyle practices such as regular exercise, adequate sleep, and stress management can complement the effects of supplementation

In the early stages, the body is in an inflammatory state, leading to an increase in metabolic rate to support the energy required for inflammation and immune responses

The importance of the CSAD enzyme is confirmed by the death of third generation (G3) CSAD KO (knock-out) mouse models within 24 h from their birth