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91 HuY.ChenW.WuL.JiangL.LiangN.TanL.et al (2019)

PMID: 36747713

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

doi: 10.3390/ijms22073789

It has been proposed that the western diet-induced intestinal ecological dysregulation and the altered intestinal barrier function can induce neuroinflammation, in turn can activate Toll-like receptors, then cause a proinflammatory response and the intestinal glial activation, ultimately contributes to the -synuclein pathology in the pathogenesis of PD (129)