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Continuous administration of a powerful growth factor can lead to receptor downregulation, diminishing its effects over time

Gut microbiota dysbiosis and metabolites (e.g., histamine, SCFAs) modulate visceral sensitivity and low-grade inflammation, affecting bowel motility, sensitivity and secretion

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Clinically, the concomitant use of resveratrol (RSV) with docetaxel (DTX) has been observed to suppress Bcl-2, amplify apoptosis, and necroptosis, thereby mitigating the drug resistance often associated with DTX monotherapy and elevating therapeutic efficacy (164)

Impaired glycolysis can be detrimental to neurons, especially during high energy demand