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AMPK-mediated BECN1 phosphorylation promotes ferroptosis by directly blocking system X(c)(-) activity

This could lead to the prediction of future escape variants and the design of vaccine antigens that encode structural epitopes that are more difficult to escape

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This metabolic switching is regulated by sirtuins, namely SIRT3 and SIRT2 repress the Warburg effect 342,343,344,345 , while SIRT5 maintains glycolysis 346