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This can be due to various factors, like increased fluid loss due to blood or diarrhea or changes in eating habits

Met Ions Life Sci 11:6383

Indeed, the homocysteine levels in patients with the risk variant (TT) were higher and their high-density lipoprotein (HDL) cholesterol levels were lower than persons not carrying this MFTR variant [9]

Therefore, ligands act as a key to the receptor and if there are increased receptors, there will be more activation in a cell of whatever effect the receptor can have on the cell