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Among these pathways, the Notch cascade, which is physiologically implicated in the differentiation of bipotent hepatoblasts into cholangiocytes, and therefore in biliary development, stands out as a critical player in lineage commitment towards the malignant cholangiocellular phenotype 134,135

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[DOI] [PMC free article] [PubMed] [Google Scholar] 78.Giacobbe J., Marrocu A., Di Benedetto M.G., Pariante C.M., Borsini A

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