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These findings suggest that the presence of CKD may influence the resolution time of the AG in specific DKA presentations

Animal studies have shown downregulation of HIF-1 and downstream pro-survival proteins (e.g., glucose transporter 1, vascular epithelial growth factor, and carbonic anhydrase) following administration of oral or parenteral vitamin C ( Figure 1 ) (Kuiper et al., 2010, 2014a