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72 However, the expression of protein markers of astrocytes and neurons is unaffected by DVS, and the chronic unpredictable mild stress (CUMS)-induced reduction in the levels of myelin- and oligodendrocyte-related proteins can be prevented by DVS

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Preclinical work has also confirmed that adeno-associated virus (AAV)-mediated delivery, such as spinal subpial delivery of AAV9, enables widespread gene silencing and can block motor neuron degeneration in rodent models of ALS (67)