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10.1039/C9SC04336E

Banned Oct 2023, reapproved March 2026

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[] Furthermore, targeting the PTMs (e.g., acetylation and small ubiquitin-like modifier conjugation [SUMOylation]) of key mitochondrial dynamics proteins such as OPA1 and DRP1 or intervening in the innate immune sensing of mtDNA (e.g., the cyclic GMP-AMP synthase-stimulator of interferon genes [cGAS-STING] pathway) offer entirely new strategies for therapeutic intervention