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EMBO J 15:17531765 Li YP, Schwartz RJ, Waddell ID, Holloway BR, Reid MB (1998) Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-B activation in response to tumor necrosis factor alpha

152,153 This effect is not influenced by chelating agents but relies on antioxidants such as N-acetylcysteine (NAC)

Sharma M, Molina CA, Toyoda K et al (2024) Safety and efficacy of factor XIa inhibition with milvexian for secondary stroke prevention (AXIOMATIC-SSP): a phase 2, international, randomised, double-blind, placebo-controlled, dose-finding trial